Postdoctoral Research Fellow - Beltran Lab
Company: Dana-Farber Cancer Institute
Location: Boston
Posted on: May 8, 2024
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Job Description:
Job ID:39683
Location:450 Brookline Ave,
Boston,
MA 02215
Category:Fellowships
Employment Type:Full time
Work Location:Onsite: 100% onsite
Overview
Located in Boston and the surrounding communities, Dana-Farber
Cancer Institute is a leader in life changing breakthroughs in
cancer research and patient care. We are united in our mission of
conquering cancer, HIV/AIDS and related diseases. We strive to
create an inclusive, diverse, and equitable environment where we
provide compassionate and comprehensive care to patients of all
backgrounds, and design programs to promote public health
particularly among high-risk and underserved populations. We
conduct groundbreaking research that advances treatment, we educate
tomorrow's physician/researchers, and we work with amazing
partners, including other Harvard Medical School-affiliated
hospitals.The Beltran Lab in Dana-Farber Cancer Institute fosters
asupportiveenvironment offering excellent scope for professional
growth. We provide robust mentorship for those on an academic track
to pursue higher education. We also have numerous collaborations
with pharmaceutical companies which provides networking
opportunities and the ability to gain transferable skillsets for
industry positions. The Beltran Lab is focused on understanding
mechanisms of treatment resistance in advanced prostate cancer
through integration of clinical and molecular features of patients
combined with preclinical modeling. We have used genomics and
epigenomics to elucidate the molecular mechanisms driving lineage
plasticity and evolution towards an androgen indifferent state. We
are developing tissue and circulating biomarkers and novel
therapeutic strategies for clinical translation. Our mission is to
make discoveries that improve the way we manage and treat patients
with advanced prostate cancer:We utilize a variety of molecular
biology and genomic and epigenomic approaches to understand
prostate cancer disease progression, therapy resistance, and tumor
heterogeneity both in patients and in preclinical models. We are
particularly focused on the emerging subset of advanced prostate
cancers that lose androgen receptor dependence as a mechanism of
treatment resistance, associated with lineage plasticity and a
change in clinical and pathologic characteristics towards a small
cell/neuroendocrine phenotype. Current projects include: 1)
Defining and validating the essential genes during neuroendocrine
prostate cancer progression using genome-scale CRISPR-Cas9
screening approaches to identify novel therapeutic targets; 2)
Understanding the genetic, epigenetic, and phenotypic changes that
drive cancer progression through bulk and single cell molecular
analyses of tumor biopsies and patient-derived models; 3)
Elucidating the mechanism, timing, and cooperation of identified
drivers including MYCN, AURKA, EZH2, RB1, and others; 4)
Characterization and preclinical testing of novel epigenetic and
immune -based therapeutic approaches and combination strategies to
treat, revert, or prevent non-AR driven resistance. Research in the
laboratory ranges from basic mechanistic investigation of cancer
gene function to highly translational genomic and functional
studies of patient-derived tissues from clinical trials. Team
members work in a highly collaborative environment that includes
laboratory investigators, clinical investigators, and computational
biologists. We are seeking an enthusiastic, dedicated, and
hardworking post-doctoral scientist to join our team. The
successful candidate will have a strong interest in cancer biology
and therapeutics with experience in molecular biology,
biochemistry, genetics/genomics or biochemistry.
Responsibilities
Qualifications
At Dana-Farber Cancer Institute, we work every day to create an
innovative, caring, and inclusive environment where every patient,
family, and staff member feels they belong. As relentless as we are
in our mission to reduce the burden of cancer for all, we are
equally committed to diversifying our faculty and staff. Cancer
knows no boundaries and when it comes to hiring the most dedicated
and diverse professionals, neither do we. If working in this kind
of organization inspires you, we encourage you to apply.
Job ID:39683
Location:450 Brookline Ave,
Boston,
MA 02215
Category:Fellowships
Employment Type:Full time
Work Location:Onsite: 100% onsite
Keywords: Dana-Farber Cancer Institute, Malden , Postdoctoral Research Fellow - Beltran Lab, Healthcare , Boston, Massachusetts
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