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Research Scientist I, Antibody Discovery and Engineering

Company: Takeda Pharmaceutical
Location: Malden
Posted on: January 10, 2022

Job Description:

By clicking the -Apply - button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda 's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Scientist I, Antibody Discovery and Engineering in our Cambridge, MA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.POSITION OBJECTIVES: Takeda is committed to the long-term strategy and vision to translate science into life-changing medicines that make important differences for our patients around the world. The Global Biologics team within R&D consists of approximately 85 scientists across two US sites (Cambridge MA and San Diego) and aims to discover novel therapeutic large molecule biologics serving our four main therapeutic areas Oncology, Gastroenterology, Neuroscience and Rare Disease.We are excited to pursue the search for a Research Scientist I to join our Biotherapeutic Engineering team, a group within Takeda's Global Biologics Department, reporting to the Senior Scientist, Biotherapeutic Engineering. You will join a team of motivated and enthusiastic scientists, bringing experience in antibody/biologic discovery and engineering. You will have experience in the field of antibody discovery and engineering using in vitro platforms such as phage-display or yeast-display (including FACS analysis and sorting) and in vivo methods (hybridoma or B cell sorting). High-level hands-on general molecular biology skills, applied towards library building, affinity-maturation, humanization and other engineering aspects is important. Familiarity with repertoire analysis using both NGS and Sanger sequencing methods is desirable. Familiarity with basic cell-culture techniques is desirable as well.POSITION ACCOUNTABILITIES:

  • Conduct in vivo or in vitro antibody discovery campaigns using phage, yeast, or single B-cell cloning/ hybridoma.
  • Handle and manipulate display libraries from discovery through optimization to isolate large diversity of biologics for programs.
  • Generate diverse repertoires from immunized animals to display libraries for further manipulation.
  • Generate maturation libraries for display platforms (affinity/ potency/ stability) leveraging datasets, experience, and software to improve lead candidates.
  • Prepare samples for sequencing by NGS or Sanger methodologies, including data analysis.
  • General molecular-biology tasks.
  • Perform complex research lab assignments independently.
  • Contribute to experimental design.
  • Maintain records, using electronic notebooks.
  • Help with preparation of various manuscripts, SOP's and publications, when relevant.
  • Purchasing and management of consumable stocks, as necessary for the workflow.EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
    • PhD in a scientific discipline (or equivalent), or MS with 6+ years of relevant experience, or BS with 8+ years of relevant experience..
    • Experience with standard molecular and cell biology techniques.
    • Experience with B-cell cloning/ hybridoma or display methods such as phage or yeast display.
    • Experience with NGS sample preparation and data analysis is preferred.
    • Identify problems, make recommendations and implement solutions.
    • Effective resource and time management skills.WHAT TAKEDA CAN OFFER YOU:
      • 401(k) with company match and Annual Retirement Contribution Plan
      • Tuition reimbursement Company match of charitable contributions
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach ProgramsLearn more at .Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.Empowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.This job posting excludes CO applicants.#LI-SGMEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Malden , Research Scientist I, Antibody Discovery and Engineering, Engineering , Malden, Massachusetts

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